2g02: Difference between revisions

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New page: left|200px<br /><applet load="2g02" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g02, resolution 2.50Å" /> '''Nisin cyclase'''<br ...
 
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[[Image:2g02.gif|left|200px]]<br /><applet load="2g02" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2g02, resolution 2.50&Aring;" />
'''Nisin cyclase'''<br />


==Overview==
==Nisin cyclase==
Nisin is a posttranslationally modified antimicrobial peptide that is, widely used as a food preservative. It contains five cyclic thioethers of, varying sizes that are installed by a single enzyme, NisC. Reported here, are the in vitro reconstitution of the cyclization process and the x-ray, crystal structure of the NisC enzyme. The structure reveals similarities, in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a, cysteine of a protein substrate.
<StructureSection load='2g02' size='340' side='right'caption='[[2g02]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2g02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G02 FirstGlance]. <br>
2G02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g02 OCA], [https://pdbe.org/2g02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g02 RCSB], [https://www.ebi.ac.uk/pdbsum/2g02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g02 ProSAT]</span></td></tr>
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16527981 16527981]
</table>
== Function ==
[https://www.uniprot.org/uniprot/NISC_LACLL NISC_LACLL] Could be implicated in the processing or the export process of the nisin lantibiotic.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g02_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g02 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Nair, S.K.]]
[[Category: Nair SK]]
[[Category: ZN]]
[[Category: alpha barrel]]
[[Category: alpha toroid]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:52:17 2007''

Latest revision as of 09:26, 14 February 2024

Nisin cyclase

2g02, resolution 2.50Å

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