1wkw: Difference between revisions
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< | ==Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide== | ||
<StructureSection load='1wkw' size='340' side='right'caption='[[1wkw]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1wkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkw OCA], [https://pdbe.org/1wkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkw RCSB], [https://www.ebi.ac.uk/pdbsum/1wkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkw_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wkw ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fujisaki | [[Category: Large Structures]] | ||
[[Category: Ishida | [[Category: Fujisaki H]] | ||
[[Category: Kitamura | [[Category: Ishida T]] | ||
[[Category: Matsushita | [[Category: Kitamura K]] | ||
[[Category: Miura | [[Category: Matsushita Y]] | ||
[[Category: Miyagawa | [[Category: Miura K]] | ||
[[Category: Shen | [[Category: Miyagawa H]] | ||
[[Category: Tomoo | [[Category: Shen X]] | ||
[[Category: Tomoo K]] | |||
Latest revision as of 13:31, 13 March 2024
Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide
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