3e0d: Difference between revisions

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{{Seed}}
[[Image:3e0d.png|left|200px]]


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==Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit==
The line below this paragraph, containing "STRUCTURE_3e0d", creates the "Structure Box" on the page.
<StructureSection load='3e0d' size='340' side='right'caption='[[3e0d]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e0d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E0D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene></td></tr>
{{STRUCTURE_3e0d| PDB=3e0d |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e0d OCA], [https://pdbe.org/3e0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e0d RCSB], [https://www.ebi.ac.uk/pdbsum/3e0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e0d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO3A_THEAQ DPO3A_THEAQ] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e0d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e0d ConSurf].
<div style="clear:both"></div>


===Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18691598}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18691598 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18691598}}
 
==About this Structure==
3E0D is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0D OCA].
 
==Reference==
<ref group="xtra">PMID:18691598</ref><references group="xtra"/>
[[Category: DNA-directed DNA polymerase]]
[[Category: Thermus aquaticus]]
[[Category: Thermus aquaticus]]
[[Category: Bailey, S.]]
[[Category: Bailey S]]
[[Category: Steitz, T A.]]
[[Category: Steitz TA]]
[[Category: Wing, R A.]]
[[Category: Wing RA]]
[[Category: Beta barrel]]
[[Category: Cytoplasm]]
[[Category: Dna replication]]
[[Category: Dna-directed dna polymerase]]
[[Category: Nucleotidyl transferase]]
[[Category: Nucleotidyltransferase]]
[[Category: Ob fold]]
[[Category: Polymerase]]
[[Category: Transferase]]
[[Category: Transferase/dna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:39:54 2009''

Latest revision as of 09:43, 21 February 2024

Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit

3e0d, resolution 4.60Å

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