1siq: Difference between revisions

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{{Seed}}
[[Image:1siq.png|left|200px]]


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==The Crystal Structure and Mechanism of Human Glutaryl-CoA Dehydrogenase==
The line below this paragraph, containing "STRUCTURE_1siq", creates the "Structure Box" on the page.
<StructureSection load='1siq' size='340' side='right'caption='[[1siq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1siq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SIQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
{{STRUCTURE_1siq| PDB=1siq |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1siq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1siq OCA], [https://pdbe.org/1siq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1siq RCSB], [https://www.ebi.ac.uk/pdbsum/1siq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1siq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GCDH_HUMAN GCDH_HUMAN] Defects in GCDH are the cause of glutaric aciduria type 1 (GA1) [MIM:[https://omim.org/entry/231670 231670]. GA1 is an autosomal recessive metabolic disorder characterized by progressive dystonia and athetosis due to gliosis and neuronal loss in the basal ganglia.<ref>PMID:18775954</ref> <ref>PMID:8541831</ref> <ref>PMID:9600243</ref> <ref>PMID:8900227</ref> <ref>PMID:8900228</ref> <ref>PMID:14707522</ref>
== Function ==
[https://www.uniprot.org/uniprot/GCDH_HUMAN GCDH_HUMAN] Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/si/1siq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1siq ConSurf].
<div style="clear:both"></div>


===The Crystal Structure and Mechanism of Human Glutaryl-CoA Dehydrogenase===
==See Also==
 
*[[Acyl-CoA dehydrogenase 3D structures|Acyl-CoA dehydrogenase 3D structures]]
 
*[[Glutaryl-CoA dehydrogenase|Glutaryl-CoA dehydrogenase]]
<!--  
== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_15274622}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 15274622 is the PubMed ID number.
__TOC__
-->
</StructureSection>
{{ABSTRACT_PUBMED_15274622}}
 
==About this Structure==
1SIQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SIQ OCA].
 
==Reference==
<ref group="xtra">PMID:15274622</ref><references group="xtra"/>
[[Category: Glutaryl-CoA dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Frerman, F E.]]
[[Category: Large Structures]]
[[Category: Fu, Z.]]
[[Category: Frerman FE]]
[[Category: Goodman, S.]]
[[Category: Fu Z]]
[[Category: Kim, J J.]]
[[Category: Goodman S]]
[[Category: Paschke, R.]]
[[Category: Kim JJ]]
[[Category: Wang, M.]]
[[Category: Paschke R]]
[[Category: Acyl-coa dehydrogenase]]
[[Category: Wang M]]
[[Category: Decarboxylation]]
[[Category: Flavin protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:57:10 2009''
Retrieved from "https://proteopedia.org/1siq"