2g9l: Difference between revisions
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== | ==The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction== | ||
We have applied NMR spectroscopy to determine the high-resolution | <StructureSection load='2g9l' size='340' side='right'caption='[[2g9l]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2g9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glandirana_rugosa Glandirana rugosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9l OCA], [https://pdbe.org/2g9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9l RCSB], [https://www.ebi.ac.uk/pdbsum/2g9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GGN4_GLARU GGN4_GLARU] Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We have applied NMR spectroscopy to determine the high-resolution structure of gaegurin 4, a 37-residue antimicrobial peptide from Rana rugosa, under varying hydrophobic conditions. Even in 100% H2O, gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34, similar to what has been observed in cecropin A. Functional implication of the helix-breaking kink at Gly24 in gaegurin 4 was investigated by preparing several analogs. Based upon the current and previous results, we propose a novel seaanemone-like ion pore-forming model for gaegurin 4. | |||
Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.,Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:17141187<ref>PMID:17141187</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 2g9l" style="background-color:#fffaf0;"></div> | ||
[[Category: Chi | == References == | ||
[[Category: Han | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Glandirana rugosa]] | |||
[[Category: Large Structures]] | |||
[[Category: Chi S-W]] | |||
[[Category: Han K-H]] | |||
Latest revision as of 07:54, 23 October 2024
The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction
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