2p0d: Difference between revisions

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{{Seed}}
[[Image:2p0d.png|left|200px]]


<!--
==ArhGAP9 PH domain in complex with Ins(1,4,5)P3==
The line below this paragraph, containing "STRUCTURE_2p0d", creates the "Structure Box" on the page.
<StructureSection load='2p0d' size='340' side='right'caption='[[2p0d]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2p0d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P0D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.811&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
{{STRUCTURE_2p0d| PDB=2p0d |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0d OCA], [https://pdbe.org/2p0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p0d RCSB], [https://www.ebi.ac.uk/pdbsum/2p0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p0d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHG09_HUMAN RHG09_HUMAN] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix.<ref>PMID:11396949</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/2p0d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p0d ConSurf].
<div style="clear:both"></div>


===ArhGAP9 PH domain in complex with Ins(1,4,5)P3===
==See Also==
 
*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_17339315}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 17339315 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_17339315}}
 
==About this Structure==
2P0D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0D OCA].
 
==Reference==
<ref group="xtra">PMID:17339315</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blasutig, I.]]
[[Category: Large Structures]]
[[Category: Ceccarelli, D F.J.]]
[[Category: Blasutig I]]
[[Category: Goudreault, M.]]
[[Category: Ceccarelli DFJ]]
[[Category: Pawson, T.]]
[[Category: Goudreault M]]
[[Category: Ruston, J.]]
[[Category: Pawson T]]
[[Category: Sicheri, F.]]
[[Category: Ruston J]]
[[Category: Pleckstrin homology domain]]
[[Category: Sicheri F]]
[[Category: Protein-phosphoinositide complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:20:44 2009''
Retrieved from "https://proteopedia.org/2p0d"