1klk: Difference between revisions

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{{Seed}}
[[Image:1klk.png|left|200px]]


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==CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH==
The line below this paragraph, containing "STRUCTURE_1klk", creates the "Structure Box" on the page.
<StructureSection load='1klk' size='340' side='right'caption='[[1klk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1klk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PMD:[N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE'>PMD</scene></td></tr>
{{STRUCTURE_1klk| PDB=1klk |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1klk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1klk OCA], [https://pdbe.org/1klk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1klk RCSB], [https://www.ebi.ac.uk/pdbsum/1klk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1klk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1klk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1klk ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH===
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12037296}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12037296 is the PubMed ID number.
[[Category: Pneumocystis carinii]]
-->
[[Category: Cody V]]
{{ABSTRACT_PUBMED_12037296}}
[[Category: Galitsky N]]
 
[[Category: Luft JR]]
==About this Structure==
[[Category: Pangborn W]]
1KLK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLK OCA].
[[Category: Queener SF]]
 
[[Category: Rosowsky A]]
==Reference==
<ref group="xtra">PMID:12037296</ref><references group="xtra"/>
[[Category: Dihydrofolate reductase]]
[[Category: Rattus norvegicus]]
[[Category: Cody, V.]]
[[Category: Galitsky, N.]]
[[Category: Luft, J R.]]
[[Category: Pangborn, W.]]
[[Category: Queener, S F.]]
[[Category: Rosowsky, A.]]
[[Category: Aid]]
[[Category: Antifolate]]
[[Category: Protein-inhibitor complex]]
[[Category: Structure-based design]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:29:52 2009''
Retrieved from "https://proteopedia.org/1klk"