1dvn: Difference between revisions

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{{Seed}}
[[Image:1dvn.png|left|200px]]


<!--
==LATENT FORM OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)==
The line below this paragraph, containing "STRUCTURE_1dvn", creates the "Structure Box" on the page.
<StructureSection load='1dvn' size='340' side='right'caption='[[1dvn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DVN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dvn OCA], [https://pdbe.org/1dvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dvn RCSB], [https://www.ebi.ac.uk/pdbsum/1dvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dvn ProSAT]</span></td></tr>
{{STRUCTURE_1dvn| PDB=1dvn |  SCENE= }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref>  Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
== Function ==
[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/1dvn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dvn ConSurf].
<div style="clear:both"></div>


===LATENT FORM OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)===
==See Also==
 
*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_10913251}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 10913251 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_10913251}}
 
==About this Structure==
1DVN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DVN OCA].
 
==Reference==
<ref group="xtra">PMID:10913251</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Buckley, D I.]]
[[Category: Large Structures]]
[[Category: Graham, H.]]
[[Category: Buckley DI]]
[[Category: Matthews, D J.]]
[[Category: Graham H]]
[[Category: Stout, T J.]]
[[Category: Matthews DJ]]
[[Category: Inhibitor]]
[[Category: Stout TJ]]
[[Category: Pai-1]]
[[Category: Serpin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:47:18 2009''
Retrieved from "https://proteopedia.org/1dvn"