1wlj: Difference between revisions

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{{Seed}}
[[Image:1wlj.png|left|200px]]


<!--
==human ISG20==
The line below this paragraph, containing "STRUCTURE_1wlj", creates the "Structure Box" on the page.
<StructureSection load='1wlj' size='340' side='right'caption='[[1wlj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wlj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WLJ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
{{STRUCTURE_1wlj| PDB=1wlj |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlj OCA], [https://pdbe.org/1wlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wlj RCSB], [https://www.ebi.ac.uk/pdbsum/1wlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wlj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISG20_HUMAN ISG20_HUMAN] Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.<ref>PMID:11401564</ref> <ref>PMID:12594219</ref> <ref>PMID:16033969</ref> <ref>PMID:21036379</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wlj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wlj ConSurf].
<div style="clear:both"></div>


===human ISG20===
==See Also==
 
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_15527770}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 15527770 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_15527770}}
 
==About this Structure==
1WLJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLJ OCA].
 
==Reference==
<ref group="xtra">PMID:15527770</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hamasaki, T.]]
[[Category: Large Structures]]
[[Category: Horio, T.]]
[[Category: Hamasaki T]]
[[Category: Inoue, T.]]
[[Category: Horio T]]
[[Category: Murai, M.]]
[[Category: Inoue T]]
[[Category: Ohgi, T.]]
[[Category: Murai M]]
[[Category: Tanaka, T.]]
[[Category: Ohgi T]]
[[Category: Exoribonuclease]]
[[Category: Tanaka T]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:23:04 2009''
Retrieved from "https://proteopedia.org/1wlj"