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{{Seed}}
[[Image:2gek.png|left|200px]]


<!--
==Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP==
The line below this paragraph, containing "STRUCTURE_2gek", creates the "Structure Box" on the page.
<StructureSection load='2gek' size='340' side='right'caption='[[2gek]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2gek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
{{STRUCTURE_2gek|  PDB=2gek  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gek OCA], [https://pdbe.org/2gek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gek RCSB], [https://www.ebi.ac.uk/pdbsum/2gek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gek ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP===
== Function ==
 
[https://www.uniprot.org/uniprot/PIMA_MYCS2 PIMA_MYCS2] Catalyzes the addition of a mannose residue from GDP-D-mannose to the position 2 of a phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inositola of PIM1.<ref>PMID:12068013</ref> <ref>PMID:19638342</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2GEK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEK OCA].  
Check<jmol>
 
  <jmolCheckbox>
==Reference==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2gek_consurf.spt"</scriptWhenChecked>
<ref group="xtra">PMID:16511084</ref><ref group="xtra">PMID:12068013</ref><ref group="xtra">PMID:15228522</ref><ref group="xtra">PMID:12765785</ref><ref group="xtra">PMID:12691742</ref><references group="xtra"/>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Mycobacterium smegmatis]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Alzari, P M.]]
  </jmolCheckbox>
[[Category: Buschiazzo, A.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gek ConSurf].
[[Category: Guerin, M E.]]
<div style="clear:both"></div>
[[Category: Jackson, M.]]
== References ==
[[Category: Kordulakova, J.]]
<references/>
[[Category: Binary complex]]
__TOC__
[[Category: Gt4 glycosyltransferase]]
</StructureSection>
[[Category: Mannosyltransferase]]
[[Category: Large Structures]]
[[Category: Rossmann fold]]
[[Category: Mycolicibacterium smegmatis MC2 155]]
 
[[Category: Alzari PM]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:50:39 2009''
[[Category: Buschiazzo A]]
[[Category: Guerin ME]]
[[Category: Jackson M]]
[[Category: Kordulakova J]]

Latest revision as of 09:27, 14 February 2024

Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP

2gek, resolution 2.40Å

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