1hlb: Difference between revisions

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{{Seed}}
[[Image:1hlb.png|left|200px]]


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==Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola==
The line below this paragraph, containing "STRUCTURE_1hlb", creates the "Structure Box" on the page.
<StructureSection load='1hlb' size='340' side='right'caption='[[1hlb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hlb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Molpadia_arenicola Molpadia arenicola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_1hlb|  PDB=1hlb  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hlb OCA], [https://pdbe.org/1hlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hlb RCSB], [https://www.ebi.ac.uk/pdbsum/1hlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLBC_MOLAR GLBC_MOLAR]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hlb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hlb ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray structures of two hemoglobins (Hb) from the sea cucumber Caudina arenicola (an echinoderm) have been determined: a low spin, hemichrome, monomeric Hb-C chain, and a cyanomet-liganded dimeric Hb-D chain. Attempts to obtain crystal structures of the deoxy-liganded and hemichrome forms from the same chain type have not been successful. In this work, the Hb-C chain and Hb-D chain structures are compared, and differences observed in tertiary structure related to the different ligand states for hemoglobin chains from this organism. In addition to shifts of the distal histidine and E helix, differences are noted in the position of the heme group within the heme pocket, the hydrogen bonding of the heme group to the protein, and the status of the D helix. These differences are important in understanding the ligand-linked association states of these hemoglobins. The quaternary structure of the Hb-D homodimer is compared with those from two other invertebrate hemoglobins from Scapharca inaequivalvis and Urechis caupo, which also have subunit-subunit interactions that involve the E and E' helices. The dimer interactions of the Caudina and Urechis hemoglobins are quite dissimilar. However, the dimer interface observed in cyanomet Hb-D is strikingly similar to that observed for the carbonmonoxy hemoglobin dimer from the clam, Scapharca, yet many of the key amino acid residues implicated in the cooperative mechanism of the Scapharca hemoglobin are not conserved in the Caudina hemoglobins.


======
Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola.,Mitchell DT, Kitto GB, Hackert ML J Mol Biol. 1995 Aug 18;251(3):421-31. PMID:7650740<ref>PMID:7650740</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1hlb" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_7650740}}, adds the Publication Abstract to the page
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 7650740 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_7650740}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1HLB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Caudina_arenicola Caudina arenicola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLB OCA].
[[Category: Molpadia arenicola]]
 
[[Category: Hackert ML]]
==Reference==
[[Category: Mitchell DT]]
<ref group="xtra">PMID:7650740</ref><references group="xtra"/>
[[Category: Caudina arenicola]]
[[Category: Hackert, M L.]]
[[Category: Mitchell, D T.]]
[[Category: Oxygen transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:19:30 2009''

Latest revision as of 06:06, 13 August 2026

Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola

1hlb, resolution 2.50Å

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