3b4r: Difference between revisions

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{{Seed}}
[[Image:3b4r.png|left|200px]]


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==Site-2 Protease from Methanocaldococcus jannaschii==
The line below this paragraph, containing "STRUCTURE_3b4r", creates the "Structure Box" on the page.
<StructureSection load='3b4r' size='340' side='right'caption='[[3b4r]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. The August 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4R FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3b4r|  PDB=3b4r  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4r OCA], [https://pdbe.org/3b4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4r RCSB], [https://www.ebi.ac.uk/pdbsum/3b4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4r ProSAT]</span></td></tr>
 
</table>
===Site-2 Protease from Methanocaldococcus jannaschii===
== Function ==
 
[https://www.uniprot.org/uniprot/Y392_METJA Y392_METJA] A site-2 regulated intramembrane protease (S2P), its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. Possible signals, S1P and substrates are unknown in this organism.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_18063795}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4r_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_18063795}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3B4R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4R OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b4r ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:18063795</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Feng, L.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Jeffrey, P D.]]
[[Category: Rhomboid Protease GlpG]]
[[Category: Shi, Y.]]
[[Category: Feng L]]
[[Category: Wang, Z.]]
[[Category: Jeffrey PD]]
[[Category: Wu, Z.]]
[[Category: Shi Y]]
[[Category: Yan, H.]]
[[Category: Wang Z]]
[[Category: Yan, N.]]
[[Category: Wu Z]]
[[Category: Cbs domain]]
[[Category: Yan H]]
[[Category: Hydrolase]]
[[Category: Yan N]]
[[Category: Intramembrane protease]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Transmembrane]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:27:18 2009''
Retrieved from "https://proteopedia.org/3b4r"