1ro6: Difference between revisions

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{{Seed}}
[[Image:1ro6.png|left|200px]]


<!--
==Crystal structure of PDE4B2B complexed with Rolipram (R & S)==
The line below this paragraph, containing "STRUCTURE_1ro6", creates the "Structure Box" on the page.
<StructureSection load='1ro6' size='340' side='right'caption='[[1ro6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ro6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RO6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ROL:ROLIPRAM'>ROL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1ro6| PDB=1ro6 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ro6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ro6 OCA], [https://pdbe.org/1ro6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ro6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ro6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ro6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/1ro6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ro6 ConSurf].
<div style="clear:both"></div>


===Crystal structure of PDE4B2B complexed with Rolipram (R & S)===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_15003452}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 15003452 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_15003452}}
 
==About this Structure==
1RO6 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RO6 OCA].
 
==Reference==
<ref group="xtra">PMID:15003452</ref><references group="xtra"/>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lambert, M H.]]
[[Category: Large Structures]]
[[Category: Nolte, R T.]]
[[Category: Lambert MH]]
[[Category: Rocque, W J.]]
[[Category: Nolte RT]]
[[Category: Vanderwall, D E.]]
[[Category: Rocque WJ]]
[[Category: Xu, R X.]]
[[Category: Vanderwall DE]]
[[Category: Crystal]]
[[Category: Xu RX]]
[[Category: Pde]]
[[Category: Rolipram]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:28:40 2009''
Retrieved from "https://proteopedia.org/1ro6"