1sja: Difference between revisions

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{{Seed}}
[[Image:1sja.png|left|200px]]


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==X-ray structure of o-Succinylbenzoate Synthase complexed with N-acetylmethionine==
The line below this paragraph, containing "STRUCTURE_1sja", creates the "Structure Box" on the page.
<StructureSection load='1sja' size='340' side='right'caption='[[1sja]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sja]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AME:N-ACETYLMETHIONINE'>AME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1sja|  PDB=1sja  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sja OCA], [https://pdbe.org/1sja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sja RCSB], [https://www.ebi.ac.uk/pdbsum/1sja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sja ProSAT]</span></td></tr>
 
</table>
===X-ray structure of o-Succinylbenzoate Synthase complexed with N-acetylmethionine===
== Function ==
 
[https://www.uniprot.org/uniprot/NSAR_AMYSP NSAR_AMYSP] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). Can catalyze the racemization of a broad range of N-acylamino acids, including N-acetyl-D/L-methionine, N-propionyl-D/L-methionine, N-butyryl-D/L-methionine and N-chloroacetyl-L-valine (PubMed:7766084, PubMed:10194342, PubMed:14705949, PubMed:23130969). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:14705949, PubMed:24955846). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).<ref>PMID:10194342</ref> <ref>PMID:14705949</ref> <ref>PMID:23130969</ref> <ref>PMID:24955846</ref> <ref>PMID:7766084</ref> <ref>PMID:16740275</ref> <ref>PMID:24955846</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15134446}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sja_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15134446}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1SJA is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJA OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sja ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:15134446</ref><references group="xtra"/>
<references/>
[[Category: Amycolatopsis sp.]]
__TOC__
[[Category: Garrett, J B.]]
</StructureSection>
[[Category: Gerlt, J A.]]
[[Category: Amycolatopsis sp]]
[[Category: Holden, H M.]]
[[Category: Large Structures]]
[[Category: Rayment, I.]]
[[Category: Garrett JB]]
[[Category: Taylor-Ringia, E A.]]
[[Category: Gerlt JA]]
[[Category: Thoden, J B.]]
[[Category: Holden HM]]
[[Category: Racemase]]
[[Category: Rayment I]]
 
[[Category: Taylor-Ringia EA]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:20:29 2009''
[[Category: Thoden JB]]
Retrieved from "https://proteopedia.org/1sja"