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New page: left|200px<br /><applet load="2hex" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hex, resolution 2.10Å" /> '''DECAMERS OBSERVED IN...
 
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[[Image:2hex.jpg|left|200px]]<br /><applet load="2hex" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2hex, resolution 2.10&Aring;" />
'''DECAMERS OBSERVED IN THE CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR'''<br />


==Overview==
==DECAMERS OBSERVED IN THE CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR==
The structure of bovine pancreatic trypsin inhibitor (BPTI) has been, solved at 2.1 A resolution in a new crystal form (space group P6422 with, unit-cell dimensions a = b = 95.0, c = 158.1 A). The asymmetric unit is a, pentamer, but a decamer is created by application of crystallographic, symmetry. The decamer of BPTI is only the fourth such assembly reported to, date in the Protein Data Bank.
<StructureSection load='2hex' size='340' side='right'caption='[[2hex]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2hex]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hex OCA], [https://pdbe.org/2hex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hex RCSB], [https://www.ebi.ac.uk/pdbsum/2hex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hex ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hex_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hex ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of bovine pancreatic trypsin inhibitor (BPTI) has been solved at 2.1 A resolution in a new crystal form (space group P6422 with unit-cell dimensions a = b = 95.0, c = 158.1 A). The asymmetric unit is a pentamer, but a decamer is created by application of crystallographic symmetry. The decamer of BPTI is only the fourth such assembly reported to date in the Protein Data Bank.


==About this Structure==
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor.,Lubkowski J, Wlodawer A Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):335-7. Epub 1999, Jan 1. PMID:10089443<ref>PMID:10089443</ref>
2HEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HEX OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor., Lubkowski J, Wlodawer A, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):335-7. Epub 1999, Jan 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10089443 10089443]
</div>
<div class="pdbe-citations 2hex" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[BPTI 3D structures|BPTI 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Lubkowski, J.]]
[[Category: Lubkowski J]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer A]]
[[Category: SO4]]
[[Category: blood clotting]]
[[Category: bovine pancreatic trypsin inhibitor]]
[[Category: pentameric molecule]]
 
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Retrieved from "https://proteopedia.org/2hex"