2hm9: Difference between revisions

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New page: left|200px<br /><applet load="2hm9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hm9" /> '''Solution structure of dihydrofolate reductas...
 
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[[Image:2hm9.jpg|left|200px]]<br /><applet load="2hm9" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2hm9" />
'''Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures'''<br />


==About this Structure==
==Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures==
2HM9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with TRR as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HM9 OCA].  
<StructureSection load='2hm9' size='340' side='right'caption='[[2hm9]]' scene=''>
[[Category: Dihydrofolate reductase]]
== Structural highlights ==
[[Category: Lactobacillus casei]]
<table><tr><td colspan='2'>[[2hm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HM9 FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
[[Category: Birdsall, B.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene></td></tr>
[[Category: Polshakov, V.I.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hm9 OCA], [https://pdbe.org/2hm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2hm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hm9 ProSAT]</span></td></tr>
[[Category: TRR]]
</table>
[[Category: dhfr]]
== Function ==
[[Category: inhibitor/enzyme complex]]
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
[[Category: oxidoreductase]]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/2hm9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hm9 ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:50:34 2007''
==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
</StructureSection>
[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Birdsall B]]
[[Category: Polshakov VI]]
Retrieved from "https://proteopedia.org/2hm9"