2hqp: Difference between revisions
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New page: left|200px<br /><applet load="2hqp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hqp" /> '''Solution structure of L.casei dihydrofolate ... |
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== | ==Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures== | ||
<StructureSection load='2hqp' size='340' side='right'caption='[[2hqp]]' scene=''> | |||
[[ | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQP FirstGlance]. <br> | |||
[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqp OCA], [https://pdbe.org/2hqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqp RCSB], [https://www.ebi.ac.uk/pdbsum/2hqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqp ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[ | == Function == | ||
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/2hqp_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqp ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lacticaseibacillus casei]] | |||
[[Category: Large Structures]] | |||
[[Category: Birdsall B]] | |||
[[Category: Polshakov VI]] | |||
Latest revision as of 19:02, 29 May 2024
Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures
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