1hrp: Difference between revisions

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{{Seed}}
[[Image:1hrp.png|left|200px]]


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==CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN==
The line below this paragraph, containing "STRUCTURE_1hrp", creates the "Structure Box" on the page.
<StructureSection load='1hrp' size='340' side='right'caption='[[1hrp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HRP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_1hrp|  PDB=1hrp  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrp OCA], [https://pdbe.org/1hrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hrp RCSB], [https://www.ebi.ac.uk/pdbsum/1hrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hrp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CGB3_HUMAN CGB3_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/1hrp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hrp ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.


===CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN===
Crystal structure of human chorionic gonadotropin.,Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136<ref>PMID:8202136</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1hrp" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_8202136}}, adds the Publication Abstract to the page
*[[Hormone|Hormone]]
(as it appears on PubMed at http://www.pubmed.gov), where 8202136 is the PubMed ID number.
*[[Human Follicle-Stimulating Hormone Complexed with its Receptor|Human Follicle-Stimulating Hormone Complexed with its Receptor]]
-->
== References ==
{{ABSTRACT_PUBMED_8202136}}
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
1HRP is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA].
[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
==Reference==
[[Category: Harris DC]]
<ref group="xtra">PMID:8202136</ref><references group="xtra"/>
[[Category: Isaacs NW]]
[[Category: Harris, D C.]]
[[Category: Lapthorn AJ]]
[[Category: Isaacs, N W.]]
[[Category: Lapthorn, A J.]]
[[Category: Hormone]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:54:38 2009''

Latest revision as of 06:43, 30 October 2024

CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN

1hrp, resolution 3.00Å

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