2jvz: Difference between revisions
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==Solution NMR Structure of the Second and Third KH Domains of KSRP== | |||
<StructureSection load='2jvz' size='340' side='right'caption='[[2jvz]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2jvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JVZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jvz OCA], [https://pdbe.org/2jvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jvz RCSB], [https://www.ebi.ac.uk/pdbsum/2jvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jvz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
== | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/2jvz_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jvz ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cukier | [[Category: Large Structures]] | ||
[[Category: Diaz-Moreno | [[Category: Cukier CD]] | ||
[[Category: Garcia-Mayoral | [[Category: Diaz-Moreno I]] | ||
[[Category: Hollingworth | [[Category: Garcia-Mayoral MF]] | ||
[[Category: Kelly | [[Category: Hollingworth D]] | ||
[[Category: Ramos | [[Category: Kelly G]] | ||
[[Category: Ramos A]] | |||
Latest revision as of 06:42, 1 May 2024
Solution NMR Structure of the Second and Third KH Domains of KSRP
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