3bm9: Difference between revisions

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{{Seed}}
[[Image:3bm9.png|left|200px]]


<!--
==Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90==
The line below this paragraph, containing "STRUCTURE_3bm9", creates the "Structure Box" on the page.
<StructureSection load='3bm9' size='340' side='right'caption='[[3bm9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BM9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXZ:4-BROMO-6-(6-HYDROXY-1,2-BENZISOXAZOL-3-YL)BENZENE-1,3-DIOL'>BXZ</scene></td></tr>
{{STRUCTURE_3bm9| PDB=3bm9 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bm9 OCA], [https://pdbe.org/3bm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3bm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bm9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/3bm9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bm9 ConSurf].
<div style="clear:both"></div>


===Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18197612}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18197612 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_18197612}}
 
==About this Structure==
3BM9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA].
 
==Reference==
<ref group="xtra">PMID:18197612</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arndt, K.]]
[[Category: Large Structures]]
[[Category: Boschelli, F.]]
[[Category: Arndt K]]
[[Category: Chopra, R.]]
[[Category: Boschelli F]]
[[Category: Ellingboe, J.]]
[[Category: Chopra R]]
[[Category: Golas, J.]]
[[Category: Ellingboe J]]
[[Category: Gopalsamy, A.]]
[[Category: Golas J]]
[[Category: Jacob, J.]]
[[Category: Gopalsamy A]]
[[Category: Johnson, J.]]
[[Category: Jacob J]]
[[Category: Lee, F.]]
[[Category: Johnson J]]
[[Category: Nilakantan, R.]]
[[Category: Lee F]]
[[Category: Peterson, R.]]
[[Category: Nilakantan R]]
[[Category: Shi, M.]]
[[Category: Peterson R]]
[[Category: Svenson, K.]]
[[Category: Shi M]]
[[Category: Tam, M S.]]
[[Category: Svenson K]]
[[Category: Vogan, E M.]]
[[Category: Tam MS]]
[[Category: Wen, Y.]]
[[Category: Vogan EM]]
[[Category: Alternative splicing]]
[[Category: Wen Y]]
[[Category: Atp binding domain]]
[[Category: Atp-binding]]
[[Category: Chaperone]]
[[Category: Cytoplasm]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:41:26 2009''
Retrieved from "https://proteopedia.org/3bm9"