3b5d: Difference between revisions

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{{Seed}}
[[Image:3b5d.png|left|200px]]


<!--
==EmrE multidrug transporter in complex with TPP, C2 crystal form==
The line below this paragraph, containing "STRUCTURE_3b5d", creates the "Structure Box" on the page.
<StructureSection load='3b5d' size='340' side='right'caption='[[3b5d]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B5D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4P:TETRAPHENYLPHOSPHONIUM'>P4P</scene></td></tr>
{{STRUCTURE_3b5d|  PDB=3b5d  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b5d OCA], [https://pdbe.org/3b5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b5d RCSB], [https://www.ebi.ac.uk/pdbsum/3b5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b5d ProSAT]</span></td></tr>
 
</table>
===EmrE multidrug transporter in complex with TPP, C2 crystal form===
== Function ==
 
[https://www.uniprot.org/uniprot/EMRE_ECOLI EMRE_ECOLI] Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium.<ref>PMID:7896833</ref> <ref>PMID:10681497</ref> <ref>PMID:15371426</ref>
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_18024586}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/3b5d_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_18024586}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3B5D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5D OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b5d ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:18024586</ref><references group="xtra"/>
<references/>
[[Category: Escherichia coli]]
__TOC__
[[Category: Chang, G.]]
</StructureSection>
[[Category: Chen, Y J.]]
[[Category: Escherichia coli K-12]]
[[Category: Antiport]]
[[Category: Large Structures]]
[[Category: Helical membrane protein]]
[[Category: Chang G]]
[[Category: Inner membrane]]
[[Category: Chen YJ]]
[[Category: Joint center for innovative membrane protein technology]]
[[Category: Multidrug resistance transporter]]
[[Category: Smr]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:48:58 2009''

Latest revision as of 09:27, 21 February 2024

EmrE multidrug transporter in complex with TPP, C2 crystal form

3b5d, resolution 3.80Å

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