3g5u: Difference between revisions

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'''Unreleased structure'''


The entry 3g5u is ON HOLD
==Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding==
 
<StructureSection load='3g5u' size='340' side='right'caption='[[3g5u]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
Authors: Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3g5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5U FirstGlance]. <br>
Description: Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:26:50 2009''
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5u OCA], [https://pdbe.org/3g5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5u RCSB], [https://www.ebi.ac.uk/pdbsum/3g5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5u ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Aller SG]]
[[Category: Chang G]]
[[Category: Chittaboina S]]
[[Category: Harrell PM]]
[[Category: Trinh YT]]
[[Category: Urbatsch IL]]
[[Category: Ward A]]
[[Category: Weng Y]]
[[Category: Yu J]]
[[Category: Zhang Q]]
[[Category: Zhuo R]]
Retrieved from "https://proteopedia.org/3g5u"