2kfd: Difference between revisions
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New page: '''Unreleased structure''' The entry 2kfd is ON HOLD Authors: Bonet, R., Ruiz, L., Morales, B., Macias, M. Description: Prp40 FF4 domain ''Page seeded by [http://oca.weizmann.ac.il/oc... |
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==Prp40 FF4 domain== | |||
<StructureSection load='2kfd' size='340' side='right'caption='[[2kfd]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfd OCA], [https://pdbe.org/2kfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kfd RCSB], [https://www.ebi.ac.uk/pdbsum/2kfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kfd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref> | |||
==See Also== | |||
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Bonet R]] | |||
[[Category: Macias M]] | |||
[[Category: Morales B]] | |||
[[Category: Ruiz L]] | |||
