2rol: Difference between revisions

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{{Seed}}
[[Image:2rol.jpg|left|200px]]


<!--
==Structural Basis of PxxDY motif recognition in SH3 binding==
The line below this paragraph, containing "STRUCTURE_2rol", creates the "Structure Box" on the page.
<StructureSection load='2rol' size='340' side='right'caption='[[2rol]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rol OCA], [https://pdbe.org/2rol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rol RCSB], [https://www.ebi.ac.uk/pdbsum/2rol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rol ProSAT]</span></td></tr>
{{STRUCTURE_2rol|  PDB=2rol  |  SCENE=  }}
</table>
 
== Function ==
===Structural Basis of PxxDY motif recognition in SH3 binding===
[https://www.uniprot.org/uniprot/ES8L1_HUMAN ES8L1_HUMAN] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_18644376}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 18644376 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2rol_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_18644376}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rol ConSurf].
2ROL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:18644376</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aitio, O.]]
[[Category: Large Structures]]
[[Category: Hellman, M.]]
[[Category: Aitio O]]
[[Category: Kesti, T.]]
[[Category: Hellman M]]
[[Category: Kleino, I.]]
[[Category: Kesti T]]
[[Category: Paakkonen, K.]]
[[Category: Kleino I]]
[[Category: Permi, P.]]
[[Category: Paakkonen K]]
[[Category: Saksela, K.]]
[[Category: Permi P]]
[[Category: Samuilova, O.]]
[[Category: Saksela K]]
[[Category: Tossavainen, H.]]
[[Category: Samuilova O]]
[[Category: Alternative splicing]]
[[Category: Tossavainen H]]
[[Category: Cd3e]]
[[Category: Coiled coil]]
[[Category: Complex structure]]
[[Category: Cytoplasm]]
[[Category: Eps8l1]]
[[Category: Immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Nmr]]
[[Category: Phosphoprotein]]
[[Category: Receptor]]
[[Category: Sh3]]
[[Category: Sh3 domain]]
[[Category: Splicing/signaling protein complex]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  4 14:30:54 2009''

Latest revision as of 07:05, 1 May 2024

Structural Basis of PxxDY motif recognition in SH3 binding

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