3d6a: Difference between revisions

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{{Seed}}
[[Image:3d6a.jpg|left|200px]]


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==Crystal structure of the 2H-phosphatase domain of Sts-2 in complex with tungstate.==
The line below this paragraph, containing "STRUCTURE_3d6a", creates the "Structure Box" on the page.
<StructureSection load='3d6a' size='340' side='right'caption='[[3d6a]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3d6a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
{{STRUCTURE_3d6a|  PDB=3d6a  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6a OCA], [https://pdbe.org/3d6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6a RCSB], [https://www.ebi.ac.uk/pdbsum/3d6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6a ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the 2H-phosphatase domain of Sts-2 in complex with tungstate.===
== Function ==
 
[https://www.uniprot.org/uniprot/UBS3A_MOUSE UBS3A_MOUSE] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.<ref>PMID:19196006</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/3d6a_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_19196006}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3D6A is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6A OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d6a ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:19196006</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Carpino, N.]]
[[Category: Carpino N]]
[[Category: Chen, Y.]]
[[Category: Chen Y]]
[[Category: Nassar, N.]]
[[Category: Nassar N]]
[[Category: 2h-phosphatase]]
[[Category: Hydrolase]]
[[Category: Pgm domain]]
[[Category: Sh3 domain]]
[[Category: Tungstate]]
 
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Retrieved from "https://proteopedia.org/3d6a"