3g5t: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(7 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3g5t.jpg|left|200px]]


<!--
==Crystal structure of trans-aconitate 3-methyltransferase from yeast==
The line below this paragraph, containing "STRUCTURE_3g5t", creates the "Structure Box" on the page.
<StructureSection load='3g5t' size='340' side='right'caption='[[3g5t]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3g5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.119&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=T8N:(2E)-2-(2-METHOXY-2-OXOETHYL)BUT-2-ENEDIOIC+ACID'>T8N</scene></td></tr>
{{STRUCTURE_3g5t|  PDB=3g5t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5t OCA], [https://pdbe.org/3g5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5t RCSB], [https://www.ebi.ac.uk/pdbsum/3g5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5t ProSAT], [https://www.topsan.org/Proteins/CESG/3g5t TOPSAN]</span></td></tr>
 
</table>
===Crystal structure of trans-aconitate 3-methyltransferase from yeast===
== Function ==
 
[https://www.uniprot.org/uniprot/TMT1_YEAST TMT1_YEAST] Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation.<ref>PMID:11695919</ref> <ref>PMID:15147181</ref> <ref>PMID:18092814</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3G5T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5T OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5t ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Trans-aconitate 3-methyltransferase]]
[[Category: Bingman CA]]
[[Category: Bingman, C A.]]
[[Category: Burgie ES]]
[[Category: Burgie, E S.]]
[[Category: Phillips Jr GN]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Wesenberg GE]]
[[Category: Jr., G N.Phillips.]]
[[Category: Wesenberg, G E.]]
[[Category: Center for eukaryotic structural genomic]]
[[Category: Cesg]]
[[Category: Cytoplasm]]
[[Category: Methyltransferase]]
[[Category: Phosphoprotein]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Structural genomic]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  4 15:00:15 2009''
Retrieved from "https://proteopedia.org/3g5t"