2jpe: Difference between revisions
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New page: left|200px<br /><applet load="2jpe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jpe" /> '''FHA domain of NIPP1'''<br /> ==About this S... |
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== | ==FHA domain of NIPP1== | ||
<StructureSection load='2jpe' size='340' side='right'caption='[[2jpe]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2jpe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JPE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpe OCA], [https://pdbe.org/2jpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jpe RCSB], [https://www.ebi.ac.uk/pdbsum/2jpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpe ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PP1R8_MOUSE PP1R8_MOUSE] Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development.<ref>PMID:15501817</ref> <ref>PMID:15199142</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/2jpe_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jpe ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Fujioka Y]] | |||
[[Category: Fujioka | [[Category: Inagaki F]] | ||
[[Category: Inagaki | [[Category: Kikuchi K]] | ||
[[Category: Kikuchi | [[Category: Kumeta H]] | ||
[[Category: Kumeta | [[Category: Ogura K]] | ||
[[Category: Ogura | [[Category: Tanuma N]] | ||
[[Category: Tanuma | |||
