3e32: Difference between revisions

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{{Seed}}
[[Image:3e32.jpg|left|200px]]


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==Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2==
The line below this paragraph, containing "STRUCTURE_3e32", creates the "Structure Box" on the page.
<StructureSection load='3e32' size='340' side='right'caption='[[3e32]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e32]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E32 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ED2:N-BENZYL-N-(2-{(4-CYANOPHENYL)[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]AMINO}ETHYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE'>ED2</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3e32| PDB=3e32 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e32 OCA], [https://pdbe.org/3e32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e32 RCSB], [https://www.ebi.ac.uk/pdbsum/3e32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e32 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/3e32_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e32 ConSurf].
<div style="clear:both"></div>


===Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2===
==See Also==
 
*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_19246009}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19246009 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_19246009}}
 
==About this Structure==
3E32 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E32 OCA].
 
==Reference==
<ref group="xtra">PMID:19246009</ref><references group="xtra"/>
[[Category: Protein farnesyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Beese, L S.]]
[[Category: Beese LS]]
[[Category: Hast, M A.]]
[[Category: Hast MA]]
[[Category: Antimalarial]]
[[Category: Ethylenediamine]]
[[Category: Falciparum]]
[[Category: Farnesyltransferase]]
[[Category: Ftase]]
[[Category: Inhibitor]]
[[Category: Malaria]]
[[Category: Metal-binding]]
[[Category: Phosphoprotein]]
[[Category: Plasmodium]]
[[Category: Prenyltransferase]]
[[Category: Protein farnesyltransferase]]
[[Category: Transferase]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:18:37 2009''

Latest revision as of 09:44, 21 February 2024

Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2

3e32, resolution 2.45Å

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