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New page: left|200px<br /><applet load="2mib" size="450" color="white" frame="true" align="right" spinBox="true" caption="2mib, resolution 2.84Å" /> '''THE STRUCTURE OF MUR...
 
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[[Image:2mib.jpg|left|200px]]<br /><applet load="2mib" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2mib, resolution 2.84&Aring;" />
'''THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION'''<br />


==Overview==
==THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION==
The three-dimensional structure of recombinant murine interleukin-1 beta, has been solved by X-ray crystallographic techniques to 2.8 A resolution, and refined to a crystallographic R factor of 0.192. Although murine, interleukin-1 beta crystallizes in the same space group as human, interleukin-1 beta with almost identical unit cell dimensions, the packing, of the molecules is quite different. The murine interleukin-1 beta, structure was solved by molecular replacement using the refined structure, of human interleukin-1 beta as trial structure, and found to be related to, the human structure by a nearly perfect twofold rotation about the, crystallographic y-axis and a 14 degrees rotation about the z-axis, with, no translation. The folding of murine interleukin-1 beta is similar to, that found for the human variant, consisting of 12 beta strands wrapped, around a core of hydrophobic side chains in a tetrahedron-like fashion., Significant differences with respect to the human structure are seen at, the N terminus and in 4 of the 11 loops connecting the 12 beta strands.
<StructureSection load='2mib' size='340' side='right'caption='[[2mib]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mib]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mib OCA], [https://pdbe.org/2mib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mib RCSB], [https://www.ebi.ac.uk/pdbsum/2mib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mib ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL1B_MOUSE IL1B_MOUSE] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mi/2mib_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2mib ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2MIB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2MIB OCA].
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
The structure of murine interleukin-1 beta at 2.8 A resolution., van Oostrum J, Priestle JP, Grutter MG, Schmitz A, J Struct Biol. 1991 Oct;107(2):189-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1807351 1807351]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Gruetter MG]]
[[Category: Gruetter, M.G.]]
[[Category: Priestle JP]]
[[Category: Oostrum, J.Van.]]
[[Category: Schmitz A]]
[[Category: Priestle, J.P.]]
[[Category: Van Oostrum J]]
[[Category: Schmitz, A.]]
[[Category: cytokine]]
 
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