3gg6: Difference between revisions
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==Crystal structure of the NUDIX domain of human NUDT18== | |||
<StructureSection load='3gg6' size='340' side='right'caption='[[3gg6]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3gg6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GG6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gg6 OCA], [https://pdbe.org/3gg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3gg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gg6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
== | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3gg6_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gg6 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: Berglund | [[Category: Berglund H]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Collins | [[Category: Collins R]] | ||
[[Category: Dahlgren | [[Category: Dahlgren LG]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Flodin | [[Category: Flodin S]] | ||
[[Category: Flores | [[Category: Flores A]] | ||
[[Category: Graslund | [[Category: Graslund S]] | ||
[[Category: Hammarstrom | [[Category: Hammarstrom M]] | ||
[[Category: Johansson | [[Category: Johansson A]] | ||
[[Category: Johansson | [[Category: Johansson I]] | ||
[[Category: Karlberg | [[Category: Karlberg T]] | ||
[[Category: Kotenyova | [[Category: Kotenyova T]] | ||
[[Category: | [[Category: Lehtio L]] | ||
[[Category: Moche | [[Category: Moche M]] | ||
[[Category: Nilsson | [[Category: Nilsson ME]] | ||
[[Category: Nordlund | [[Category: Nordlund P]] | ||
[[Category: Nyman | [[Category: Nyman T]] | ||
[[Category: Persson | [[Category: Persson C]] | ||
[[Category: Sagemark J]] | |||
[[Category: Sagemark | [[Category: Schueler H]] | ||
[[Category: Schueler | [[Category: Siponen MI]] | ||
[[Category: Siponen | [[Category: Thorsell AG]] | ||
[[Category: Thorsell | [[Category: Tresaugues L]] | ||
[[Category: Tresaugues | [[Category: Van Den Berg S]] | ||
[[Category: | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Welin M]] | ||
[[Category: | [[Category: Wisniewska M]] | ||
[[Category: | |||
Latest revision as of 07:05, 6 September 2023
Crystal structure of the NUDIX domain of human NUDT18
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Large Structures
- Arrowsmith CH
- Berglund H
- Bountra C
- Collins R
- Dahlgren LG
- Edwards AM
- Flodin S
- Flores A
- Graslund S
- Hammarstrom M
- Johansson A
- Johansson I
- Karlberg T
- Kotenyova T
- Lehtio L
- Moche M
- Nilsson ME
- Nordlund P
- Nyman T
- Persson C
- Sagemark J
- Schueler H
- Siponen MI
- Thorsell AG
- Tresaugues L
- Van Den Berg S
- Weigelt J
- Welin M
- Wisniewska M
