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{{Seed}}
[[Image:3ebi.png|left|200px]]


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==Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog==
The line below this paragraph, containing "STRUCTURE_3ebi", creates the "Structure Box" on the page.
<StructureSection load='3ebi' size='340' side='right'caption='[[3ebi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ebi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EBI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEY:(2S)-3-[(R)-[(1S)-1-AMINO-3-PHENYLPROPYL](HYDROXY)PHOSPHORYL]-2-BENZYLPROPANOIC+ACID'>BEY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3ebi| PDB=3ebi |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ebi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ebi OCA], [https://pdbe.org/3ebi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ebi RCSB], [https://www.ebi.ac.uk/pdbsum/3ebi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ebi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3ebi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ebi ConSurf].
<div style="clear:both"></div>


===Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog===
==See Also==
 
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_19196988}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 19196988 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_19196988}}
[[Category: Plasmodium falciparum FcB1/Columbia]]
 
[[Category: Buckle AM]]
==About this Structure==
[[Category: McGowan S]]
3EBI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EBI OCA].
[[Category: Porter CJ]]
 
[[Category: Whisstock JC]]
==Reference==
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase., McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP, Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19196988 19196988]
[[Category: Plasmodium falciparum]]
[[Category: Single protein]]
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
[[Category: Aminopeptidase]]
[[Category: Cytoplasm]]
[[Category: Hydrolase]]
[[Category: Hydrolase inhibitor]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Protease]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 18 20:35:23 2009''

Latest revision as of 09:46, 21 February 2024

Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog

3ebi, resolution 2.00Å

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