2kbp: Difference between revisions

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[[Image:2kbp.jpg|left|200px]]


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==Solution structure of a G-quadruplex of human telomeric RNA==
The line below this paragraph, containing "STRUCTURE_2kbp", creates the "Structure Box" on the page.
<StructureSection load='2kbp' size='340' side='right'caption='[[2kbp]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kbp]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbp OCA], [https://pdbe.org/2kbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbp RCSB], [https://www.ebi.ac.uk/pdbsum/2kbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbp ProSAT]</span></td></tr>
{{STRUCTURE_2kbp|  PDB=2kbp  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Very recent studies showed that mammalian telomeres were transcribed into telomeric-repeat-containing RNAs and suggested that these RNA molecules were biologically important. Here we report on a structural study of RNA G-quadruplexes formed by human telomeric RNA sequences in K(+) solution. Our data indicated that these sequences formed propeller-type parallel-stranded RNA G-quadruplexes. We have determined the NMR-based solution structure of a dimeric propeller-type RNA G-quadruplex formed by the 12-nt human telomeric RNA sequence r(UAGGGUUAGGGU). We also observed the stacking of two such propeller-type G-quadruplex blocks for the 10-nt human telomeric RNA sequence r(GGGUUAGGGU) and a higher-order G-quadruplex structure for the 9-nt human telomeric RNA sequence r(GGGUUAGGG). Based on these findings we proposed how higher-order structures might be formed by long telomeric RNA.


===Solution structure of a G-quadruplex of human telomeric RNA===
Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution.,Martadinata H, Phan AT J Am Chem Soc. 2009 Feb 25;131(7):2570-8. PMID:19183046<ref>PMID:19183046</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2kbp" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19183046 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19183046}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2KBP is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBP OCA].
[[Category: Martadinata H]]
 
[[Category: Phan AT]]
==Reference==
<ref group="xtra">PMID:19183046</ref><references group="xtra"/>
[[Category: Martadinata, H.]]
[[Category: Phan, A T.]]
[[Category: G-quadruplex]]
[[Category: Parallel form]]
[[Category: Rna]]
[[Category: Telomeric]]
 
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Latest revision as of 12:50, 20 December 2023

Solution structure of a G-quadruplex of human telomeric RNA

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