3gc0: Difference between revisions

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{{Seed}}
[[Image:3gc0.jpg|left|200px]]


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==Structure of the CMGC CDK Kinase from Giardia lamblia in complex with AMP==
The line below this paragraph, containing "STRUCTURE_3gc0", creates the "Structure Box" on the page.
<StructureSection load='3gc0' size='340' side='right'caption='[[3gc0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_lamblia_ATCC_50803 Giardia lamblia ATCC 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GC0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
{{STRUCTURE_3gc0|  PDB=3gc0  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gc0 OCA], [https://pdbe.org/3gc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gc0 RCSB], [https://www.ebi.ac.uk/pdbsum/3gc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gc0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A8BZ95_GIAIC A8BZ95_GIAIC]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/3gc0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gc0 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Giardia lamblia is the etiologic agent of giardiasis, a water-borne infection that is prevalent throughout the world. The need for new therapeutics for the treatment of giardiasis is of paramount importance. Owing to the ubiquitous nature of kinases and their vital importance in organisms, they are potential drug targets. In this paper, the first structure of a cyclin-dependent kinase (CDK) from G. lamblia (GlCDK; UniProt A8BZ95) is presented. CDKs are cell-cycle-associated kinases that are actively being pursued as targets for anticancer drugs as well as for antiparasitic chemotherapy. Generally, a CDK forms a complex with its associated cyclin. This CDK-cyclin complex is active and acts as a serine/threonine protein kinase. Typically, CDKs are responsible for the transition to the next phase of the cell cycle. Although the structure of GlCDK with its associated cyclin was not solved, the 1.85 A resolution structure of apo GlCDK and a 2.0 A resolution structure of GlCDK in complex with adenosine monophosphate are presented and the structural differences from the orthologous human CDK2 and CDK3 are discussed.


===Structure of the CMGC CDK Kinase from Giardia lamblia in complex with AMP===
Structure of a cyclin-dependent kinase from Giardia lamblia.,Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1084-9. Epub 2011 Aug 16. PMID:21904054<ref>PMID:21904054</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
3GC0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GC0 OCA].
<div class="pdbe-citations 3gc0" style="background-color:#fffaf0;"></div>
[[Category: Giardia lamblia atcc 50803]]
== References ==
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
<references/>
[[Category: Amp]]
__TOC__
[[Category: Atp-binding]]
</StructureSection>
[[Category: Cmgc cdk]]
[[Category: Giardia lamblia ATCC 50803]]
[[Category: Kinase]]
[[Category: Large Structures]]
[[Category: Nucleotide-binding]]
[[Category: Seattle structural genomics center for infectious disease]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Ssgcid]]
[[Category: Structural genomic]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:42:23 2009''

Latest revision as of 07:03, 6 September 2023

Structure of the CMGC CDK Kinase from Giardia lamblia in complex with AMP

3gc0, resolution 2.00Å

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