2kgr: Difference between revisions

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{{Seed}}
[[Image:2kgr.jpg|left|200px]]


<!--
==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
The line below this paragraph, containing "STRUCTURE_2kgr", creates the "Structure Box" on the page.
<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
{{STRUCTURE_2kgr| PDB=2kgr |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].
<div style="clear:both"></div>


===Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A===
==See Also==
 
*[[Intersectin|Intersectin]]
 
== References ==
==About this Structure==
<references/>
2KGR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Acton, T.]]
[[Category: Large Structures]]
[[Category: Ciccosanti, C.]]
[[Category: Acton T]]
[[Category: Everett, J.]]
[[Category: Ciccosanti C]]
[[Category: Ghosh, A.]]
[[Category: Everett J]]
[[Category: Hua, J.]]
[[Category: Ghosh A]]
[[Category: Jiang, M.]]
[[Category: Hua J]]
[[Category: Montelione, G.]]
[[Category: Jiang M]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione G]]
[[Category: Shastry, R.]]
[[Category: Shastry R]]
[[Category: Swapna, G.]]
[[Category: Swapna G]]
[[Category: Szyperski, T.]]
[[Category: Szyperski T]]
[[Category: Wu, Y.]]
[[Category: Wu Y]]
[[Category: Xiao, R.]]
[[Category: Xiao R]]
[[Category: Zhang, Q.]]
[[Category: Zhang Q]]
[[Category: Alternative splicing]]
[[Category: Calcium]]
[[Category: Cell junction]]
[[Category: Cell projection]]
[[Category: Coiled coil]]
[[Category: Endocytosis]]
[[Category: Membrane]]
[[Category: Nesg]]
[[Category: Nmr]]
[[Category: Northeast structural genomics consortium]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Sh3 domain]]
[[Category: Structural genomic]]
[[Category: Structure]]
[[Category: Synapse]]
[[Category: Synaptosome]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  2 16:09:28 2009''
Retrieved from "https://proteopedia.org/2kgr"