3gcn: Difference between revisions

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{{Seed}}
[[Image:3gcn.jpg|left|200px]]


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==Crystal structure of DegS H198P/D320A mutant modified by DFP in complex with OMP peptide (YQF)==
The line below this paragraph, containing "STRUCTURE_3gcn", creates the "Structure Box" on the page.
<StructureSection load='3gcn' size='340' side='right'caption='[[3gcn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GCN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>
-->
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gco|3gco]], [[3gds|3gds]], [[3gdu|3gdu]], [[3gdv|3gdv]]</div></td></tr>
{{STRUCTURE_3gcn|  PDB=3gcn  |  SCENE=  }}
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3235, degS, hhoB, htrH, JW3204 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gcn OCA], [https://pdbe.org/3gcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gcn RCSB], [https://www.ebi.ac.uk/pdbsum/3gcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gcn ProSAT]</span></td></tr>
===Crystal structure of DegS H198P/D320A mutant modified by DFP in complex with OMP peptide (YQF)===
</table>
 
== Function ==
 
[[https://www.uniprot.org/uniprot/DEGS_ECOLI DEGS_ECOLI]] When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMPs) and then initiates RseA (anti sigma-E factor) degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by RseP. This cascade that ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly.<ref>PMID:12183369</ref> <ref>PMID:19695325</ref> 
==About this Structure==
== Evolutionary Conservation ==
3GCN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCN OCA].  
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Escherichia coli k-12]]
Check<jmol>
[[Category: Grant, R A.]]
  <jmolCheckbox>
[[Category: Sauer, R T.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/3gcn_consurf.spt"</scriptWhenChecked>
[[Category: Sohn, J.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gcn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Grant, R A]]
[[Category: Sauer, R T]]
[[Category: Sohn, J]]
[[Category: Htra]]
[[Category: Htra]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Hydrolase/hydrolase activator complex]]
[[Category: Hydrolase-hydrolase activator complex]]
[[Category: Omp]]
[[Category: Omp]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
[[Category: Periplasm]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Stress-sensor]]
[[Category: Stress-sensor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  2 16:13:44 2009''
Retrieved from "https://proteopedia.org/3gcn"