2p1z: Difference between revisions

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New page: left|200px<br /><applet load="2p1z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p1z, resolution 2.44Å" /> '''Crystal structure of...
 
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[[Image:2p1z.jpg|left|200px]]<br /><applet load="2p1z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2p1z, resolution 2.44&Aring;" />
'''Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae'''<br />


==About this Structure==
==Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae==
2P1Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Active as [http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2P1Z OCA].  
<StructureSection load='2p1z' size='340' side='right'caption='[[2p1z]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2p1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P1Z FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pyrE, DIP2097 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=257309 CORDI])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1z OCA], [https://pdbe.org/2p1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p1z RCSB], [https://www.ebi.ac.uk/pdbsum/2p1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1z ProSAT], [https://www.topsan.org/Proteins/MCSG/2p1z TOPSAN]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/Q6NF12_CORDI Q6NF12_CORDI]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).[HAMAP-Rule:MF_01208][SAAS:SAAS00015698]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1z ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Cordi]]
[[Category: Large Structures]]
[[Category: Orotate phosphoribosyltransferase]]
[[Category: Chang, C]]
[[Category: Clancy, S]]
[[Category: Joachimiak, A]]
[[Category: Li, H]]
[[Category: Structural genomic]]
[[Category: Corynebacterium diphtheriae]]
[[Category: Corynebacterium diphtheriae]]
[[Category: Orotate phosphoribosyltransferase]]
[[Category: Mcsg]]
[[Category: Single protein]]
[[Category: Phosphoribosyltransferase]]
[[Category: Chang, C.]]
[[Category: PSI, Protein structure initiative]]
[[Category: Clancy, S.]]
[[Category: Transferase]]
[[Category: Joachimiak, A.]]
[[Category: Li, H.]]
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
[[Category: corynebacterium diphtheriae]]
[[Category: mcsg]]
[[Category: midwest center for structural genomics]]
[[Category: phosphoribosyltransferase]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: structural genomics]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:23:14 2007''

Latest revision as of 13:12, 9 June 2021

Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae

2p1z, resolution 2.44Å

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