3gmd: Difference between revisions

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'''Unreleased structure'''


The entry 3gmd is ON HOLD
==Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I==
<StructureSection load='3gmd' size='340' side='right'caption='[[3gmd]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3gmd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GMD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2M3:2-METHYL-3-{(3S)-1-[(1-PYRIDIN-2-YLCYCLOPROPYL)CARBONYL]PYRROLIDIN-3-YL}-1H-PYRROLO[2,3-B]PYRIDINE'>2M3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gmd OCA], [https://pdbe.org/3gmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gmd RCSB], [https://www.ebi.ac.uk/pdbsum/3gmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gmd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.


Authors: Valeur, E., Lepifre, F., Roche, D., Christmann-Franck, S., Hillertz, P., Musil, D.
==See Also==
 
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
Description: Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I
__TOC__
 
</StructureSection>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:54:57 2009''
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Christmann-Franck S]]
[[Category: Hillertz P]]
[[Category: Lepifre F]]
[[Category: Musil D]]
[[Category: Roche D]]
[[Category: Valeur E]]
Retrieved from "https://proteopedia.org/3gmd"