2pva: Difference between revisions

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New page: left|200px<br /><applet load="2pva" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pva, resolution 2.50Å" /> '''OXIDIZED PENICILLIN ...
 
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[[Image:2pva.gif|left|200px]]<br /><applet load="2pva" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2pva, resolution 2.50&Aring;" />
'''OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS'''<br />


==About this Structure==
==OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS==
2PVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus] with DTD as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA].  
<StructureSection load='2pva' size='340' side='right'caption='[[2pva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pva OCA], [https://pdbe.org/2pva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pva RCSB], [https://www.ebi.ac.uk/pdbsum/2pva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pva ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pva_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pva ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members., Suresh CG, Pundle AV, SivaRaman H, Rao KN, Brannigan JA, McVey CE, Verma CS, Dauter Z, Dodson EJ, Dodson GG, Nat Struct Biol. 1999 May;6(5):414-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10331865 10331865]
*[[Penicillin acylase|Penicillin acylase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lysinibacillus sphaericus]]
[[Category: Lysinibacillus sphaericus]]
[[Category: Penicillin amidase]]
[[Category: Brannigan JA]]
[[Category: Single protein]]
[[Category: Dauter Z]]
[[Category: Brannigan, J.A.]]
[[Category: Dodson EJ]]
[[Category: Dauter, Z.]]
[[Category: Dodson GG]]
[[Category: Dodson, E.J.]]
[[Category: McVey CE]]
[[Category: Dodson, G.G.]]
[[Category: Pundle AV]]
[[Category: McVey, C.E.]]
[[Category: Rao KN]]
[[Category: Pundle, A.V.]]
[[Category: SivaRaman H]]
[[Category: Rao, K.N.]]
[[Category: Suresh CG]]
[[Category: SivaRaman, H.]]
[[Category: Verma CS]]
[[Category: Suresh, C.G.]]
[[Category: Verma, C.S.]]
[[Category: DTD]]
[[Category: amidohydrolase]]
[[Category: ntn hydrolase]]
[[Category: penicillin v acylase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:41:50 2007''

Latest revision as of 00:22, 28 December 2023

OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS

2pva, resolution 2.50Å

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