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New page: left|200px<br /><applet load="2px7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2px7, resolution 2.200Å" /> '''Crystal structure o...
 
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[[Image:2px7.jpg|left|200px]]<br /><applet load="2px7" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2px7, resolution 2.200&Aring;" />
'''Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8'''<br />


==About this Structure==
==Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8==
2PX7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb27 Thermus thermophilus hb27]. Active as [http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PX7 OCA].  
<StructureSection load='2px7' size='340' side='right'caption='[[2px7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2px7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PX7 FirstGlance]. <br>
[[Category: Thermus thermophilus hb27]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Chang, S-H.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2px7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2px7 OCA], [https://pdbe.org/2px7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2px7 RCSB], [https://www.ebi.ac.uk/pdbsum/2px7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2px7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2px7 TOPSAN]</span></td></tr>
[[Category: Chen, L-Q.]]
</table>
[[Category: Chen, L.]]
== Function ==
[[Category: Ebihara, A.]]
[https://www.uniprot.org/uniprot/ISPD_THET8 ISPD_THET8] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
[[Category: Kuramitsu, S.]]
== Evolutionary Conservation ==
[[Category: Lee, D.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Liu, Z-J.]]
Check<jmol>
[[Category: Nguyen, D.]]
  <jmolCheckbox>
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2px7_consurf.spt"</scriptWhenChecked>
[[Category: Rose, J.P.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: SECSG, Southeast.Collaboratory.for.Structural.Genomics.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Shinkai, A.]]
  </jmolCheckbox>
[[Category: Tsukuda, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2px7 ConSurf].
[[Category: Wang, B-C.]]
<div style="clear:both"></div>
[[Category: Yokoyama, S.]]
[[Category: 2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase]]
[[Category: ispd]]
[[Category: ispd_thet8]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: secsg]]
[[Category: southeast collaboratory for structural genomics]]
[[Category: structural genomics]]
[[Category: ttha0171]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:43:02 2007''
==See Also==
*[[MEP cytidylyltransferase 3D structures|MEP cytidylyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus HB8]]
[[Category: Chang S-H]]
[[Category: Chen L]]
[[Category: Chen L-Q]]
[[Category: Ebihara A]]
[[Category: Kuramitsu S]]
[[Category: Lee D]]
[[Category: Liu Z-J]]
[[Category: Nguyen D]]
[[Category: Rose JP]]
[[Category: Shinkai A]]
[[Category: Tsukuda M]]
[[Category: Wang B-C]]
[[Category: Yokoyama S]]

Latest revision as of 11:11, 30 August 2023

Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8

2px7, resolution 2.20Å

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