3em2: Difference between revisions

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{{Seed}}
[[Image:3em2.png|left|200px]]


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==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6038==
The line below this paragraph, containing "STRUCTURE_3em2", creates the "Structure Box" on the page.
<StructureSection load='3em2' size='340' side='right'caption='[[3em2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3em2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EM2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NCE:3,6-BIS[(3-MORPHOLINOPROPIONAMIDO)]+ACRIDINE'>NCE</scene></td></tr>
{{STRUCTURE_3em2|  PDB=3em2  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3em2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3em2 OCA], [https://pdbe.org/3em2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3em2 RCSB], [https://www.ebi.ac.uk/pdbsum/3em2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3em2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.


===A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6038===
Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19173611}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3em2" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19173611 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19173611}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3EM2 is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EM2 OCA].
[[Category: Campbell NH]]
 
[[Category: Neidle S]]
==Reference==
[[Category: Parkinson G]]
<ref group="xtra">PMID:19173611</ref><references group="xtra"/>
[[Category: Campbell, N H.]]
[[Category: Neidle, S.]]
[[Category: Parkinson, G.]]
[[Category: Anti-parallel]]
[[Category: Bimolecular]]
[[Category: Bsu-6038]]
[[Category: Bsu6038]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Macromolecule]]
[[Category: Oxytricha nova]]
[[Category: Quadruplex]]
 
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Retrieved from "https://proteopedia.org/3em2"