3e2f: Difference between revisions

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{{Seed}}
[[Image:3e2f.png|left|200px]]


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==Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form==
The line below this paragraph, containing "STRUCTURE_3e2f", creates the "Structure Box" on the page.
<StructureSection load='3e2f' size='340' side='right'caption='[[3e2f]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E2F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
{{STRUCTURE_3e2f|  PDB=3e2f  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e2f OCA], [https://pdbe.org/3e2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e2f RCSB], [https://www.ebi.ac.uk/pdbsum/3e2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e2f ProSAT]</span></td></tr>
 
</table>
===Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form===
== Function ==
 
[https://www.uniprot.org/uniprot/KAT3_MOUSE KAT3_MOUSE] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).<ref>PMID:19029248</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/3e2f_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_19029248}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3E2F is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E2F OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e2f ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:19029248</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Cai, T.]]
[[Category: Cai T]]
[[Category: Han, Q.]]
[[Category: Han Q]]
[[Category: Li, J.]]
[[Category: Li J]]
[[Category: Robinson, R.]]
[[Category: Robinson R]]
[[Category: Tagle, D A.]]
[[Category: Tagle DA]]
[[Category: Alpha beta protein]]
[[Category: Alternative splicing]]
[[Category: Aminotransferase]]
[[Category: Lyase]]
[[Category: Plp dependent protein]]
[[Category: Pyridoxal phosphate]]
[[Category: Transferase]]
 
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Retrieved from "https://proteopedia.org/3e2f"