3ey2: Difference between revisions

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{{Seed}}
[[Image:3ey2.jpg|left|200px]]


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==A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution==
The line below this paragraph, containing "STRUCTURE_3ey2", creates the "Structure Box" on the page.
<StructureSection load='3ey2' size='340' side='right'caption='[[3ey2]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ey2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EY2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N3D:N-METHYLPROPANE-1,3-DIAMINE'>N3D</scene>, <scene name='pdbligand=USM:2-S-METHYL-2-THIOURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>USM</scene></td></tr>
{{STRUCTURE_3ey2|  PDB=3ey2  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ey2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ey2 OCA], [https://pdbe.org/3ey2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ey2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ey2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ey2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.


===A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution===
A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.,Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M Chem Commun (Camb). 2009 Apr 21;(15):2017-9. Epub 2009 Feb 26. PMID:19333476<ref>PMID:19333476</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_19333476}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3ey2" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19333476 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19333476}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3EY2 is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EY2 OCA].
[[Category: Egli M]]
 
[[Category: Pallan PS]]
==Reference==
<ref group="xtra">PMID:19333476</ref><references group="xtra"/>
[[Category: Egli, M.]]
[[Category: Pallan, P S.]]
[[Category: 2'-thiomethyl modified dna]]
[[Category: Modified sugar]]
[[Category: Nucleic acid structure.]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 09:44:27 2009''

Latest revision as of 06:37, 6 September 2023

A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution

3ey2, resolution 1.04Å

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