2zpu: Difference between revisions

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{{Seed}}
[[Image:2zpu.jpg|left|200px]]


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==Crystal Structure of Modified Serine Racemase from S.pombe.==
The line below this paragraph, containing "STRUCTURE_2zpu", creates the "Structure Box" on the page.
<StructureSection load='2zpu' size='340' side='right'caption='[[2zpu]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZPU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene></td></tr>
{{STRUCTURE_2zpu|  PDB=2zpu  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zpu OCA], [https://pdbe.org/2zpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zpu RCSB], [https://www.ebi.ac.uk/pdbsum/2zpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zpu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRR_SCHPO SRR_SCHPO] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/2zpu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zpu ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Serine racemase synthesizes d-serine, a physiological agonist of the NMDA receptor in mammalian brains. Schizosaccharomyces pombe produces serine racemase (spSR) that is highly similar to the brain enzyme. Our mass-spectrometric and X-ray studies revealed that spSR is modified with its natural substrate serine. spSR remains partially active even though its essential Lys57 inherently forming a Schiff base with the coenzyme pyridoxal 5'-phosphate is converted to N(6)-(R-2-amino-2-carboxyethyl)-l-lysyl (lysino-d-alanyl) residue. This indicates that the alpha-amino group of the d-alanyl moiety of the lysino-d-alanyl residue serves as a catalytic base in the same manner as the epsilon-amino group of Lys57 of the original spSR.


===Crystal Structure of Modified Serine Racemase from S.pombe.===
Serine racemase with catalytically active lysinoalanyl residue.,Yamauchi T, Goto M, Wu HY, Uo T, Yoshimura T, Mihara H, Kurihara T, Miyahara I, Hirotsu K, Esaki N J Biochem. 2009 Apr;145(4):421-4. Epub 2009 Jan 20. PMID:19155267<ref>PMID:19155267</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_19155267}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2zpu" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19155267 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19155267}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2ZPU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZPU OCA].
 
==Reference==
<ref group="xtra">PMID:19155267</ref><references group="xtra"/>
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Serine racemase]]
[[Category: Goto M]]
[[Category: Goto, M.]]
[[Category: Isomerase]]
[[Category: Lyase]]
[[Category: Plp-dependent]]
[[Category: Pyridoxal phosphate]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 09:56:23 2009''

Latest revision as of 01:34, 21 November 2024

Crystal Structure of Modified Serine Racemase from S.pombe.

2zpu, resolution 1.70Å

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