3fpp: Difference between revisions

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{{Seed}}
[[Image:3fpp.jpg|left|200px]]


<!--
==Crystal structure of E.coli MacA==
The line below this paragraph, containing "STRUCTURE_3fpp", creates the "Structure Box" on the page.
<StructureSection load='3fpp' size='340' side='right'caption='[[3fpp]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FPP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpp OCA], [https://pdbe.org/3fpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fpp RCSB], [https://www.ebi.ac.uk/pdbsum/3fpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpp ProSAT]</span></td></tr>
{{STRUCTURE_3fpp|  PDB=3fpp  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of E.coli MacA===
[https://www.uniprot.org/uniprot/MACA_ECOLI MACA_ECOLI] Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), suggesting that the system could also transport R-LPS or a similar glycolipid.<ref>PMID:11544226</ref> <ref>PMID:17214741</ref> <ref>PMID:18955484</ref> <ref>PMID:21696464</ref> <ref>PMID:23974027</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_19254725}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 19254725 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fp/3fpp_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_19254725}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fpp ConSurf].
3FPP is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPP OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:19254725</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Ha, N C.]]
[[Category: Large Structures]]
[[Category: Piao, S.]]
[[Category: Ha N-C]]
[[Category: Xu, Y.]]
[[Category: Piao S]]
[[Category: Yum, S.]]
[[Category: Xu Y]]
[[Category: Antibiotic resistance]]
[[Category: Yum S]]
[[Category: Cell inner membrane]]
[[Category: Cell membrane]]
[[Category: Drug efflux pump]]
[[Category: Hexameric assembly]]
[[Category: Membrane]]
[[Category: Membrane fusion protein]]
[[Category: Membrane protein]]
[[Category: Periplasmic protein]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 10:05:28 2009''
Retrieved from "https://proteopedia.org/3fpp"