Sandbox 70

Please do NOT make changes to this Sandbox until after April 30, 2009. Sandboxes 60-80 are reserved until then for use by students of East High, Buffalo NY. About Topoisomerases You may wonder about the structure of DNA such as is it tangled or does it become stressed? Well the answer is yes but there a protein that relaxes and untangles DNA,it is called Topoisomerases.Topoisomerases is a protein that untangles and relax DNA. Function Topoisomerases wraps itself around DNA and makes a cut in one strand. While holding that damaged area, the enzyme allows the helix to spin, relaxing any tangled or untangled. After DNA relaxed,topoisomerase reconnects the broken strand, then returning DNA double helix back. Structural Properties Topoisomerases is mostly apla heliex,it also has beta sheet's and that concect each other. So there primary and secondary and 3rd level and maybe the 4th levl of structure spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1a36' size='350' frame='false' scene= 1a36, resolution 2.80Å (default scene) Activity: DNA topoisomerase, with EC number 5.99.1.2 Structural annotation: Resources: CATH : 1A36A03, 1A36A02, 1A36A01, 1A36A04 InterPro : Ipr011010, Ipr009054, Ipr013500, Ipr013499, Ipr001631, Ipr013030, Ipr008336, Ipr014727, Ipr014711 Pfam : PF02919, PF01028 SCOP : d1a36a2, d1a36a1, d1a36a3 UniProt : P11387 Functional annotation: Cellular component: nucleolus perikaryon chromosome nucleoplasm cytoplasm nucleus Biological process: DNA unwinding during replication response to drug embryonic cleavage phosphorylation DNA topological change programmed cell death DNA replication Molecular function: DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity DNA binding chromatin binding protein binding isomerase activity DNA topoisomerase type I activity Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB Resources: FirstGlance, OCA, RCSB, PDBsum Coordinates: save as pdb, mmCIF, xml