3h8q: Difference between revisions
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New page: '''Unreleased structure''' The entry 3h8q is ON HOLD Authors: Chaikuad, A., Johansson, C., Ugochukwu, E., Roos, A.K., von Delft, F., Pilka, E., Yue, W., Arrowsmith, C.H., Edwards, A.M.,... |
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==Crystal structure of glutaredoxin domain of human thioredoxin reductase 3== | |||
<StructureSection load='3h8q' size='340' side='right'caption='[[3h8q]], [[Resolution|resolution]] 2.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3h8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H8Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h8q OCA], [https://pdbe.org/3h8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h8q RCSB], [https://www.ebi.ac.uk/pdbsum/3h8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h8q ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRXR3_HUMAN TRXR3_HUMAN] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).[UniProtKB:Q99MD6] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h8q_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h8q ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Chaikuad A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Johansson C]] | |||
[[Category: Oppermann U]] | |||
[[Category: Pilka E]] | |||
[[Category: Roos AK]] | |||
[[Category: Ugochukwu E]] | |||
[[Category: Weigelt J]] | |||
[[Category: Yue W]] | |||
[[Category: Von Delft F]] | |||
