2sak: Difference between revisions

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New page: left|200px<br /><applet load="2sak" size="450" color="white" frame="true" align="right" spinBox="true" caption="2sak, resolution 1.8Å" /> '''STAPHYLOKINASE (SAKST...
 
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[[Image:2sak.jpg|left|200px]]<br /><applet load="2sak" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2sak, resolution 1.8&Aring;" />
'''STAPHYLOKINASE (SAKSTAR VARIANT)'''<br />


==Overview==
==STAPHYLOKINASE (SAKSTAR VARIANT)==
The three-dimensional structure of staphylokinase has been determined at, 1.8 A. The puntative site of interaction with plasminogen was identified, and epitopes were mapped.
<StructureSection load='2sak' size='340' side='right'caption='[[2sak]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2sak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SAK FirstGlance]. <br>
2SAK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with TRS as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2SAK OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sak OCA], [https://pdbe.org/2sak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sak RCSB], [https://www.ebi.ac.uk/pdbsum/2sak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sak ProSAT]</span></td></tr>
Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential., Rabijns A, De Bondt HL, De Ranter C, Nat Struct Biol. 1997 May;4(5):357-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9145104 9145104]
</table>
[[Category: Single protein]]
== Function ==
[https://www.uniprot.org/uniprot/SAK_STAAU SAK_STAAU] Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1:1 complex with plasmin, which in turn activates other plasminogen molecules.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/2sak_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2sak ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Bondt, H.L.De.]]
[[Category: De Bondt HL]]
[[Category: Lasters, I.]]
[[Category: De Maeyer M]]
[[Category: Maeyer, M.De.]]
[[Category: De Ranter C]]
[[Category: Rabijns, A.]]
[[Category: Lasters I]]
[[Category: Ranter, C.De.]]
[[Category: Rabijns A]]
[[Category: TRS]]
[[Category: fibrinolysis]]
[[Category: hydrolase]]
[[Category: plasminogen activation]]
[[Category: staphylokinase]]
 
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Retrieved from "https://proteopedia.org/2sak"