3efd: Difference between revisions

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{{Seed}}
[[Image:3efd.png|left|200px]]


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==The crystal structure of the cytoplasmic domain of KcsA==
The line below this paragraph, containing "STRUCTURE_3efd", creates the "Structure Box" on the page.
<StructureSection load='3efd' size='340' side='right'caption='[[3efd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3efd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3EFD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3efd OCA], [http://pdbe.org/3efd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3efd RCSB], [http://www.ebi.ac.uk/pdbsum/3efd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3efd ProSAT]</span></td></tr>
-->
</table>
{{STRUCTURE_3efd|  PDB=3efd  |  SCENE=  }}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/3efd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3efd ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
KcsA is a proton-activated, voltage-modulated K(+) channel that has served as the archetype pore domain in the Kv channel superfamily. Here, we have used synthetic antigen-binding fragments (Fabs) as crystallographic chaperones to determine the structure of full-length KcsA at 3.8 A, as well as that of its isolated C-terminal domain at 2.6 A. The structure of the full-length KcsA-Fab complex reveals a well-defined, 4-helix bundle that projects approximately 70 A toward the cytoplasm. This bundle promotes a approximately 15 degrees bending in the inner bundle gate, tightening its diameter and shifting the narrowest point 2 turns of helix below. Functional analysis of the full-length KcsA-Fab complex suggests that the C-terminal bundle remains whole during gating. We suggest that this structure likely represents the physiologically relevant closed conformation of KcsA.


===The crystal structure of the cytoplasmic domain of KcsA===
Crystal structure of full-length KcsA in its closed conformation.,Uysal S, Vasquez V, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A Proc Natl Acad Sci U S A. 2009 Apr 3. PMID:19346472<ref>PMID:19346472</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3efd" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19346472}}, adds the Publication Abstract to the page
*[[Antibody 3D structures|Antibody 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19346472 is the PubMed ID number.
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
-->
== References ==
{{ABSTRACT_PUBMED_19346472}}
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
3EFD is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFD OCA].
 
==Reference==
<ref group="xtra">PMID:19346472</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Esaki, K.]]
[[Category: Esaki, K]]
[[Category: Fellouse, F A.]]
[[Category: Fellouse, F A]]
[[Category: Koide, S.]]
[[Category: Koide, S]]
[[Category: Kossiakoff, A.]]
[[Category: Kossiakoff, A]]
[[Category: Perozo, E.]]
[[Category: Perozo, E]]
[[Category: Sidhu, S S.]]
[[Category: Sidhu, S S]]
[[Category: Tereshko, V.]]
[[Category: Tereshko, V]]
[[Category: Uysal, S.]]
[[Category: Uysal, S]]
[[Category: Vasquez, V.]]
[[Category: Vasquez, V]]
[[Category: C-terminus]]
[[Category: C-terminus]]
[[Category: Helix bundle]]
[[Category: Helix bundle]]
[[Category: Immune system]]
[[Category: Immune system]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  6 10:07:31 2009''
Retrieved from "https://proteopedia.org/3efd"