2kdp: Difference between revisions

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{{Seed}}
[[Image:2kdp.png|left|200px]]


<!--
==Solution Structure of the SAP30 zinc finger motif==
The line below this paragraph, containing "STRUCTURE_2kdp", creates the "Structure Box" on the page.
<StructureSection load='2kdp' size='340' side='right'caption='[[2kdp]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KDP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2kdp| PDB=2kdp |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdp OCA], [https://pdbe.org/2kdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kdp RCSB], [https://www.ebi.ac.uk/pdbsum/2kdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAP30_HUMAN SAP30_HUMAN] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9651585</ref> [UniProtKB:O88574]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kdp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kdp ConSurf].
<div style="clear:both"></div>


===Solution Structure of the SAP30 zinc finger motif===
==See Also==
 
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_19223330}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 19223330 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_19223330}}
 
==About this Structure==
2KDP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDP OCA].
 
==Reference==
<ref group="xtra">PMID:19223330</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: He, Y.]]
[[Category: Large Structures]]
[[Category: Imhoff, R.]]
[[Category: He Y]]
[[Category: Radhakrishnan, I.]]
[[Category: Imhoff R]]
[[Category: Sahu, A.]]
[[Category: Radhakrishnan I]]
[[Category: Nucleic acid interaction]]
[[Category: Sahu A]]
[[Category: Nucleus]]
[[Category: Repressor]]
[[Category: Sap30]]
[[Category: Sin3]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc finger motif]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:05:20 2009''
Retrieved from "https://proteopedia.org/2kdp"