2kim: Difference between revisions

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New page: '''Unreleased structure''' The entry 2kim is ON HOLD Authors: Aramini, J.M., Belote, R.L., Ciccosanti, C.T., Jiang, M., Rost, B., Nair, R., Swapna, G.VT., Acton, T.B., Xiao, R., Everett...
 
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'''Unreleased structure'''


The entry 2kim is ON HOLD
==1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.==
<StructureSection load='2kim' size='340' side='right'caption='[[2kim]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_AQ3810 Vibrio parahaemolyticus AQ3810]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kim OCA], [https://pdbe.org/2kim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kim RCSB], [https://www.ebi.ac.uk/pdbsum/2kim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kim ProSAT], [https://www.topsan.org/Proteins/NESGC/2kim TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATL_VIBPQ ATL_VIBPQ] Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).[UniProtKB:P0AFP2]<ref>PMID:20212037</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/2kim_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kim ConSurf].
<div style="clear:both"></div>


Authors: Aramini, J.M., Belote, R.L., Ciccosanti, C.T., Jiang, M., Rost, B., Nair, R., Swapna, G.VT., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T.
==See Also==
 
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
Description: 1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:21:08 2009''
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio parahaemolyticus AQ3810]]
[[Category: Acton TB]]
[[Category: Aramini JM]]
[[Category: Belote RL]]
[[Category: Ciccosanti CT]]
[[Category: Everett JK]]
[[Category: Jiang M]]
[[Category: Montelione GT]]
[[Category: Nair R]]
[[Category: Rost B]]
[[Category: Swapna GVT]]
[[Category: Xiao R]]
Retrieved from "https://proteopedia.org/2kim"